STABILITY OF A TRIPLE-SOLUTION CONTAINING ROPIVACAINE, KETOROLAC AND EPINEPHRINE
J. Nejatbakhsh, B. Madsen, H. Jespersen and B. Sønniksen.
The Pharmacy Department at Aarhus University Hospital, Denmark
Background: The ambition for The Pharmacy Department at Aarhus University Hospital is to provide drugs that are as ready to use as possible, to minimize errors and enhancing drug safety for patients and to quality assure the handling of drugs. The Department of Orthopaedic Surgery uses a triple-solution containing ropivacaine, ketorolac and epinephrine for local and intraarticular infiltration. The clinical staff on the ward used to prepare the solution. In accordance with the ambition the Pharmacy is now producing the triple-solution. This is made possible by cooperation between The Acute Pain Service, the departments for Clinical Pharmacy, Quality Assurance and the Production Unit at the Pharmacy.
Methods: The triple-solution was quantitative measured for ropivacaine, ketorolac and epinephrine by reverse phase high-performance liquid chromatography (HPLC). Furthermore, pH value was measured, particle content was tested and the Container Closure Integrity Test was performed.
Results: The concentration of ropivacaine, ketorolac and epinephrine decreased respectively 1%, 2% and 10% during storage at 4°C for 20 days and 48 hours at 22°C. None of the tested batches contain less than 90% of the declared content of the three
components.
Conclusion: The triple-solution remained stable during 20 days at 2-8 °C, followed by 48 hours of storage below 25 °C. The Pharmacy now has a regular delivery of the triple-solution to several departments at the hospital.
Reference: 13th EAHP Congress, Maastricht, the Netherlands, 27-29 February 2008
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